Perez utilized photography early on in his development as an artist. Running a genetics lab at Columbia University for over 11 years, it was there when he was introduced to photographic development in the darkroom before digital media production was readily available, as well as, the first versions of Photoshop. He was an early adopter of digital photography, surreptitiously buying his first digital camera from a Sony employee before the market was aware. His early works were reproductions in charcoal on paper and wood of his black and white photographs shot with a Pentax SLR with Ilford HP5 film, then manipulated repeatedly after the darkroom through such items as scanners and photocopiers, and later in software. Photography eventually matured into its own medium in his oeuvre. Perez's fine art photography is shot predominantly in black and white, with few exceptions in color like his ON THE OUTSIDE series.